Overview of instructions and reviews on the use of cough tablets Bromhexine and their analogues. Tablets "Bromhexine" for children: instructions for use Contraindications for use

An expectorant drug that helps to facilitate the process of sputum production, reduces its viscosity.

The drug is taken orally in the form of tablets. Has a slight antitussive effect. During the course of treatment with the drug, a large amount of liquid should be consumed in order to improve the mucolytic effect of the drug.

In this article, we will consider why doctors prescribe Bromhexine, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Bromhexine can be read in the comments.

Composition and form of release

Bromhexine is available in the form:

Tablets 8 mg (in cell packs and jars of various packaging);
Tablets for children 4 mg (in blisters of 10 pieces);
Oral solution 4 mg / 5 ml (in vials of 100 ml);
Syrup 4 mg / 5 ml (in vials of 100 ml).

One tablet contains:

active substance: bromhexine hydrochloride in terms of 100% substance - 4 mg or 8 mg;
excipients: lactose monohydrate 60 mg or 120 mg, potato starch 4 mg or 8 mg, calcium stearate 1 mg or 2 mg, sodium carboxymethyl starch 1 mg or 2 mg, sucrose (sugar) 30 mg or 60 mg, respectively.

The drug belongs to the drugs that stimulate the motor function of the respiratory tract and secretolikam.

What is Bromhexine used for?

The use of Bromhexine is advisable in the treatment of respiratory diseases, the course of which is associated with the formation of a difficult-to-separate viscous secret:

Tracheobronchitis;
Bronchial asthma;
chronic pneumonia;
Chronic bronchitis with a broncho-obstructive component;
Cystic fibrosis.

In addition, the drug is used during diagnostic and therapeutic intrabronchial manipulations and in the preoperative period for the rehabilitation of the bronchial tree, as well as for the prevention of the accumulation of thick viscous sputum in the bronchi after surgery.

Pharmacological effects

The drug Bromhexine contributes to the provision of a secretolytic (mucolytic) effect, has an expectorant and weak antitussive effect. The use of this medication allows you to reduce the viscosity of sputum, increase its volume and facilitate the process of its removal. The therapeutic effect of Bromhexine develops after 2-5 days of use.

The use of the drug Bromhexine (including tablets) promotes the production of acid-neutral polysaccharides that destroy acidic ones. In addition, the active substance of the drug increases the activity of the bronchi, which contributes to the expectorant effect. As the viscous sputum is evacuated, the bronchial microflora is restored.

Instructions for use

According to the instructions for use, the therapeutic effect of the use of Bromhexine appears after about 2-5 days. The duration of the course of treatment is 4-28 days, depending on the severity of the disease.

Tablets for adults and children over 10 years old - 8 mg 3-4 times / day. Children under the age of 2 years - 2 mg 3 times / day; at the age of 2 to 6 years - 4 mg 3 times / day; at the age of 6 to 10 years - 6-8 mg 3 times / day. If necessary, the dose can be increased for adults up to 16 mg 4 times / day, for children - up to 16 mg 2 times / day.
In the form of inhalations for adults - 8 mg each, children over 10 years old - 4 mg each, at the age of 6-10 years - 2 mg each. At the age of 6 years - used in doses up to 2 mg. Inhalations are carried out 2 times / day.

Contraindications

Hypersensitivity to bromhexine.

Side effects

When using Bromhexine, certain adverse reactions may develop:

Respiratory system: bronchospasm, cough.
Central nervous system: dizziness, headache.
Dermatological reactions: skin rash, increased sweating, itching, rhinitis, urticaria, angioedema.
Digestive system: dyspepsia, abdominal pain, transient increase in the activity of liver enzymes in the blood serum, exacerbation of peptic ulcer.

Pregnancy and lactation

During pregnancy and lactation, Bromhexine is used in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

special instructions

Bromhexine is not prescribed simultaneously with drugs containing codeine, as this makes it difficult to expectorate liquefied sputum. The therapeutic effect of the drug may appear on the 4th-6th day of treatment. In children, treatment should be combined with postural drainage and chest vibration massage, which facilitates the outflow of secretions from the bronchi. During pregnancy, the drug is prescribed only if the therapeutic effect exceeds the risk.

Analogues

The drug has certain analogues:

For solution: Bromhexine-Egis, Bromhexine Nycomed, Bromhexine 4 Berlin-Chemie.
For tablets: Solvin, Bromhexine MS, Bromhexine Obolenskoye, Bromhexine-Egis, Bromhexine-UBF.
For syrup: Bronchostop, Bromhexine-Acri.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of BROMHEXIN in pharmacies (Moscow) is 15 rubles.

Terms and conditions of storage

Bromhexine should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C. The shelf life of the drug is 5 years.

The drug "Bromhexine" for children is indicated in the presence of diseases of the respiratory tract in young patients. This secretomotor and secretolytic drug has excellent mucolytic properties, due to which sputum is discharged from the child after the first days of treatment without much difficulty. In addition, the above agent is an activator of the motor, that is, the motor function of the respiratory tract.

The drug "Bromhexine" for children: a brief description

The instruction characterizes this tool as a powerful mucolytic drug that has an amazing therapeutic effect. The drug has an antitussive and expectorant effect.

Without a special prescription in a pharmacy, you can buy Bromhexine. Its price is approximately 71 rubles. for 1 bottle (100 ml).

The above medicine is recommended to be stored at normal room temperature. Keep it in a dry and dark place, away from children. The drug should not be used after the expiration of its period of use, which is about three years.

Release form and composition of the drug

The therapeutic agent "Bromhexine" for children is produced by the manufacturer in tablet and syrup form. One pill contains 4 mg of bromhexine hydrochloride. There are 10 or 20 tablets in one package.

Bromhexine (5 mg syrup) contains 4 mg bromhexine hydrochloride, 2 g sorbitol, 96% ethanol (alcohol), 5 mg methyl p-hydroxybenzoate. The excipients that are included in the above preparation are propylene glycol, succinic acid, apricot flavor, sodium benzoate, eucalyptus oil, purified water. One vial contains 100 mg of medicine.

pharmachologic effect

The drug "Bromhexine" for children is used as a powerful antitussive. It has the following effects on the respiratory tract of young patients:

Indications and contraindications

The drug "Bromhexine" for children, the instruction advises to use with symptoms of the following diseases:

cystic fibrosis;
pneumonia;
emphysema;
tracheobronchitis;
pulmonary tuberculosis;
bronchiectasis;
sanitation of the bronchial tree (during preparation for surgery, in the postoperative period to prevent the accumulation of viscous sputum, during intrabronchial diagnostic and therapeutic manipulations);
obstructive bronchitis.

The drug "Bromhexine" (tablets, syrup) instructions do not recommend using if a small patient has the following health problems:

in the stage of exacerbation peptic ulcer of the stomach;
gastroduodenitis;
hypersensitivity to the ingredients of the above remedy;
kidney failure;
fructose intolerance (hereditary);
liver failure;
bleeding in the stomach, which is in history;
bronchial disease, which is accompanied by an excessive accumulation of secrets.

Experts warn that it is very important to observe the indicated dosages and in no case exceed them. After all, this can lead to the formation of side effects in young patients. For example, there have been cases of children developing allergies, nausea, dizziness, exacerbation of gastroduodenitis, headache, vomiting, and an increase in liver transaminase activity after taking this drug.

When observing any of the above signs, parents should immediately show the child to the attending physician and stop giving him Bromhexine. Instructions for use indicate that in some cases, in some patients, the occurrence of such a side effect as angioedema, in other words, allergic Quincke's edema, was recorded.

Treatment of drug overdose involves the following actions:

inducing artificial vomiting;
gastric lavage.

An overdose of this drug does not cause life-threatening symptoms.

Tablets (syrup) "Bromhexine" and other drugs

It should be taken into account when taking the above medication and its interaction with other drugs. For example, this drug is completely incompatible with alkaline solutions. In no case should the above medicine be prescribed together with antitussives, since in most cases they complicate the process of sputum production.

The drug "Bromhexine" promotes the penetration of sulfanilamide drugs and antibiotics (cephalexin, amoxicillin) into the bronchial secretion during the first 5 days of antimicrobial treatment.

How to take Bromhexine for small patients?

Instructions for use for children advise the following doses of the above medication, depending on their age:

babies under 2 years old are recommended to use 2.5 ml or 2 mg every 8 hours;
babies aged 2 to 6 years should take 5 ml or 4 mg of medication three times a day;
for small patients who are from 6 to 14 years old, it is recommended to use 10 ml and 8 mg of the drug every 8 hours;
children over 14 years old can take 16 mg or 20 ml of the drug three times a day.

It is important to drink the drug with a sufficiently large amount of liquid to maintain the secretolytic effect of the main substance.

Taking the medicine "Bromhexine" (syrup, tablets), the instruction advises to combine with vibration massage of the chest of small patients or with postural drainage. Such therapy facilitates the evacuation of secretions from the bronchi.

The instruction draws attention to the fact that if the child does not have a therapeutic effect during the first 4 days, then parents should consult a doctor.

An hour after the use of the above medication, its maximum concentration in the blood is reached.

Bromhexine is an excellent mucolytic drug for young patients.

Bromhexine: instructions for use and reviews

Latin name: Bromhexine

ATX code: R05CB02

Active substance: Bromhexine (Bromhexine)

Producer: Pharmasyntez OJSC, Dalkhimpharm OJSC, Jodillia-Pharm LLC, PFC Updating CJSC, Bioreactor LLC, Valenta Pharmaceuticals OJSC, Pharmstandard-Leksredstva OJSC, KhFK Akrikhin OJSC, CJSC "Vifitech", JSC "Biosintez" (Russia)

Description and photo update: 12.08.2019

Bromhexine is a mucolytic agent with an expectorant effect.

Release form and composition

Tablets 8 mg (in cell packs and jars of various packaging);
Tablets for children 4 mg (in blisters of 10 pieces);
Oral solution 4 mg / 5 ml (in vials of 100 ml);
Syrup 4 mg / 5 ml (in vials of 60 and 100 ml).

The active substance of the drug is bromhexine hydrochloride.

Pharmacological properties

Pharmacodynamics

Bromhexine is a prodrug that is converted to ambroxol in the body. The drug enhances the activity of goblet cell lysosomes, which are part of the epithelium of the respiratory tract. This leads to the release of lysosomal enzymes responsible for the hydrolysis of mucoproteins and mucopolysaccharides. Bromhexine hydrochloride activates the production of surfactant and neutral polysaccharides, and also normalizes mucociliary clearance. This compound provides liquefaction of the bronchial secretion of increased viscosity and stickiness and its removal from the bronchi. Bromhexine is characterized by antitussive action.

Pharmacokinetics

Bromhexine crosses the placental and blood-brain barriers. It binds to plasma proteins by 99%. There is also the effect of "first pass" through the liver, in which the biotransformation of the active component of the drug occurs with the formation of the active metabolite - ambroxol. The therapeutic effect becomes noticeable after 20-30 minutes after ingestion. The half-life is 6.5 hours, increasing with chronic renal failure. Bromhexine is excreted through the kidneys as metabolites by about 85-90% and tends to accumulate in the body.

Indications for use

The use of Bromhexine is advisable in the treatment of respiratory diseases, the course of which is associated with the formation of a difficult-to-separate viscous secret:

Chronic bronchitis with a broncho-obstructive component;
Tracheobronchitis;
Bronchial asthma;
chronic pneumonia;
Cystic fibrosis.

Contraindications

A contraindication to the use of the drug is the patient's hypersensitivity to bromhexine.

Instructions for use Bromhexine: method and dosage

Bromhexine solution, tablets and syrup are taken orally.

The dosage is determined based on the age of the patient:

Children under 2 years of age are recommended to take 2 mg 3 times a day;
Children from 2 to 6 years old - 4 mg 3 times a day;
Children from 6 to 10 years old - 6-8 mg 3 times a day;
Children over 10 years old and adults - 8 mg 3 times a day;
If necessary, the dose can be increased: for adults - up to 16 mg 4 times a day, for children - up to 16 mg 2 times a day.

The use of the drug in the form of inhalation:

Children under 6 years old - up to 2 mg 2 times a day;
Children from 6 to 10 years old - 2 mg 2 times a day;
Children over 10 years old - 4 mg 2 times a day;
Adults - 8 mg 2 times a day.

The therapeutic effect usually appears on the 4th-6th day of application. The duration of treatment is from 4 to 28 days.

Parenteral administration is used in severe cases and in the postoperative period, in order to prevent the accumulation of thick sputum in the bronchi. The drug is administered (intravenously or intramuscularly) 2-3 times a day, 2 mg slowly over 3 minutes.

Side effects

From the side of the central nervous system: dizziness and headaches;
From the respiratory system: bronchospasm, cough;
From the digestive system: a transient increase in the activity of hepatic transaminases in the blood serum, dyspeptic manifestations;
Dermatological reactions: skin rash, excessive sweating.

Overdose

When taking too high doses of Bromhexine, symptoms such as diarrhea, dyspepsia, nausea, and vomiting may occur. In this case, symptomatic treatment is recommended.

special instructions

In the treatment of patients suffering from gastric ulcer, as well as those with a history of gastric bleeding, the use of the drug should be carried out under the supervision of a physician.

Patients diagnosed with bronchial asthma Bromhexine is prescribed with caution.

Bromhexine can be used as part of combined herbal preparations containing essential oils (including menthol, eucalyptus oil, peppermint, anise).

Use during pregnancy and lactation

According to the instructions, Bromhexine in any dosage form is contraindicated in the first trimester of pregnancy. In the II and III trimesters, the appointment of the drug is possible after a thorough study of the ratio of the benefits of therapy for the mother and potential risks to the fetus. During the course of treatment with Bromhexine, it is necessary to stop breastfeeding.

drug interaction

When Bromhexine is combined with antitussive drugs, sputum discharge may be difficult against the background of a weakening of the cough reflex. The drug is pharmaceutically incompatible with alkaline solutions (pH over 6.3).

Analogues

Bromhexine's analogues are:

for tablets: Solvin, Bromhexine MS, Bromhexine Obolenskoye, Bromhexine-Egis, Bromhexine-UBF;
for solution: Bromhexine-Egis, Bromhexine Nycomed, Bromhexine 4 Berlin-Chemie;
for syrup: Bronchostop, Bromhexine-Acri.

Terms and conditions of storage

The shelf life of tablets and syrup is 5 years, the solution is 3 years. Store in a dry, dark place and out of the reach of children. Store syrup and tablets at a temperature not exceeding 25 ° C, solution - not higher than 30 ° C.

The composition of 1 tablet and 5 ml of syrup may include 4 mg or 8 mg bromhexine , according to INN (international non-proprietary name) - Bromhexine.

Release form

The main forms of release of the drug are Bromhexine tablets from 10 to 100 pieces per pack and Bromhexine syrup 50, 60 or 100 ml per vial.

pharmachologic effect

Antitussive, secretolytic (mucolytic), expectorant.

Pharmacodynamics and pharmacokinetics

The therapeutic agent Bromhexine is characterized secretolytic (mucolytic) and expectorant properties, from which tablets and syrup of the drug will be used for dry cough in adults and children. Secretolytic efficiency bromhexine manifested through his ability liquefy And depolymerize mucoprotein and mucopolysaccharide fibers bronchial secretion . Also of no small importance in the effectiveness of treatment bromhexine has stimulation of their education surfactant , a surface-active substance that lines the inside lung alveoli thereby increasing the protective function of the pulmonary system. In addition to its main effects, the drug has a weak antitussive impact.

Oral (by mouth) intake bromhexine leads to its almost complete absorption (99%) from the gastrointestinal tract within 30 minutes. Because of the effect first pass » Through the liver, the drug has low bioavailability (about 20%). Plasma protein binding is quite high. Able to penetrate placental And blood-brain barriers . Hepatic metabolic transformations take place due to oxidation And demethylation . T1 / 2 due to slow reverse tissue diffusion averages 15 hours. Excretion is carried out mostly by the kidneys. Has the ability to cumulation in organism. At excretion of products is disturbed.

Indications for use

Indications for the use of Bromhexine are painful conditions of the bronchopulmonary system in the presence of difficult viscous sputum ( , lungs , , pneumoconiosis, cystic fibrosis , bronchiectasis, , obstructive , pneumonia ).

Also, the drug is used in the preoperative period for sanitation (recovery) bronchial tree ; in the postoperative period for prophylactic removal of mucus accumulation in the bronchi; in diagnostic and therapeutic clinical intrabronchial manipulations .

Contraindications

Before taking Bromhexine in tablets or syrup, you should familiarize yourself with the contraindications to its use.

Absolute contraindications include:

Gastrointestinal tract in the period of exacerbation;
in the first trimester;
children's age up to 2 years for syrup and up to 6 years for tablets;
personal hypersensitivity ;
sugar intolerance .

Carefully:

/ ;
tendency to gastrointestinal tract ;
bronchopulmonary painful conditions with accumulation too much secretion ;
pregnancy in the second and third trimester.

Side effects

manifestations;
nausea, vomiting;
feeling ;
exacerbation of peptic ulcer;
(skin rash / , , and etc.);
increase in liver activity.

Instructions for use Bromhexine

Bromhexine tablets, instructions for use

Bromhexine tablets are intended for oral (by mouth) administration. Tablets can be taken regardless of food intake with 100-200 ml of water. Adults are shown a single dose of 8-16 mg of the drug 3-4 times in 24 hours. From 6 to 14 years old, 3 times daily intake of 8 mg is practiced. The effect of therapy can develop only for 4-6 days.

Bromhexine syrup, instructions for use

The syrup of the drug is mainly intended for use in pediatrics, although it does not preclude the use of the drug by adult patients in the same dosages and frequency of administration as prescribed for tablets (8-16 mg 3-4 times a day).

Children's syrup is available with a mass content of the active ingredient 4mg / 5ml and is often provided with a measuring beaker for ease of dosing, such as syrup Bromhexine Nycomed , measuring cup or spoon.

Instructions for use Bromhexine for children recommends patients aged 2-6 years taking 2.5-5 ml (2-4 mg); 6-10 years - 5-10 ml (4-8 mg); after 10 years - 10 ml (8 mg) syrup for children three times a day.

When using children's Bromhexine, it is recommended to use in parallel vibration massage baby's chest or procedure postural drainage , in order to further facilitate secretion discharge .

The course of treatment of any of the pharmacological forms of the drug can last from 4 to 28 days. During therapy, the patient should be provided with a sufficient amount of fluid to maintain a productive secretory action.

Overdose

Overdose symptoms may be nausea followed by vomiting or without it, and other disorders dyspeptic character.

If overdose phenomena are detected in the first 60-120 minutes, the patient should be called vomit And gastric lavage . Subsequently, symptomatic treatment is indicated.

Interaction

Do not prescribe in parallel with antitussive drugs (for example, ), due to difficulty in the discharge of bronchial secretions.

Combined reception with NSAIDs can irritate the mucous membranes of the gastrointestinal tract and even lead to the formation and ulcers .

The use of Bromhexine favors penetration into bronchial secretions sulfanilamide LS and ( , , , ), in the first 4-5 days of antibiotic therapy.

Terms of sale

Any of the pharmacological forms of the drug can be purchased without presenting a prescription in Latin.

Storage conditions

The maximum temperature at which tablets and syrup can be stored should not exceed 25 ° C.

Best before date

Most often, tablets and syrup (closed bottle) can be stored for 3 years.

Analogues

Coincidence in the ATX code of the 4th level:

In the event that for some reason the use of Bromhexine is impossible, the doctor may advise the following analogues:

Acestine ;
Bronchoxol ;
etc.

children

The instructions for the drug prohibit taking tablets up to 6 years and taking syrup up to 2 years.

The main prescribed dosage form Bromhexine for children from 2 to 6 years, due to the possibility of more accurate dosing (measuring spoon or beaker) and ease of swallowing, is an oral syrup for children used in the above dosages. Mass fraction bromhexine in tablets for children is 4 mg and is prescribed to children who have reached the age of 6 in doses corresponding to their age category.

Bromhexine during pregnancy and lactation

The drug in any form is contraindicated in the first trimester. In the second and third trimester, its appointment is possible only in extreme cases, consistent with the principle - benefit / risk to the mother / fetus.

If necessary, treatment with Bromhexine need to be suspended.

Reviews about Bromhexine

As a rule, reviews of Bromhexine of adult patients who understand exactly what the drug tablets are for, namely, for liquefaction of viscous sputum with a view to its speedy removal, are positive. The drug in most cases perfectly copes with its task and practically, with rare exceptions, does not lead to side effects. The situation is a little more complicated when the issue concerns small patients and their mothers who want to cure their child's cough as soon as possible and in the case when this does not happen quickly, they are ready to speak negatively about any drug. Let us remind you once again that Bromhexine syrup for children is designed to solve the problem softening of bronchial secretions , and various bronchopulmonary diseases may require therapy with different drugs from many drug groups and often in combination. Therefore, before giving your baby any medicine, you just need to seek qualified advice from a pediatrician and strictly follow his instructions.

Bromhexine price, where to buy

The price of the drug, depending on the manufacturer and the number of tablets or the volume of the bottle, is somewhat different, but remains within the limits available to almost every consumer.

So the price of Bromhexine in tablets 8 mg No. 50 varies from 25 to 50 rubles; the price of syrup Bromhexine 8 mg / 5 ml 150 ml is within 150 rubles, and syrup for children 4 mg / 5 ml 100 ml can be bought for 60-80 rubles.

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ZdravCity

Bromhexine tablets 8mg 20 pcs. JSC Akrikhin

Bromhexine tablets 0.008g 50 pcs. Ozone LLC

Bromhexine tablets 8mg 28 pcs.JSC PFC Renewal

Bromhexine-Akrikhin syrup 4mg/5ml 100mlMedana Pharma A.O.

Bromhexine tablets 4mg 50 pcs. JSC Akrikhin

Pharmacy Dialog

Bromhexine-Akrikhin tablets 8mg №20 Akrikhin OAO

Bromhexine tablets 8mg №28PFC CJSC update

Bromhexine vial 4mg 60ml Berlin-Chemie AG/Menarini

Bromhexine dragee 8mg №25 Berlin-Chemie AG/Menarini

Bromhexine Nycomed vial 0.8mg/ml 150ml Nycomed

Europharm * 4% discount with promo code medical11

Bromhexine-acriquine syrup 4 mg/5 ml 100 ml Medana Pharma JSC

Bromhexine-acriquine 8 mg 20 tab. JSC Akrikhin

LP-004535-131117

Trade name of the drug:

Bromhexine

International non-proprietary name:

bromhexine

Dosage form:

tablets for children

Compound:

for 1 tablet:
active substance: bromhexine hydrochloride - 4.00 mg.
Excipients: lactose monohydrate (milk sugar) - 80.23 mg; corn starch - 11.54 mg; povidone K-25 - 3.46 mg; magnesium stearate - 0.77 mg.

Description:

round flat-cylindrical tablets of white or almost white color with a chamfer and a risk mark.

Pharmacotherapeutic group:

mucolytic expectorant.

ATX code:

R05CB02

Pharmacological properties

Pharmacodynamics
Mucolytic (secregolytic) agent, has an expectorant and weak antitussive effect. Reduces the viscosity of sputum (depolymerizes mucoprotein and mucopolysaccharide fibers, increases the serous component of bronchial secretion); activates ciliated epithelium, increases volume and improves sputum discharge.
Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells during respiration. The effect appears after 2-5 days from the start of treatment.

Pharmacokinetics
When administered orally, Bromhexine is almost completely (99%) absorbed into the gastrointestinal tract within 30 minutes. Bioavailability - low (the effect of the primary "passage" through the liver). Bromhexine in plasma binds to proteins, penetrates the blood-brain and placental barriers, as well as into breast milk. In the liver, bromhexine undergoes demethylation and oxidation, and is metabolized to the pharmacologically active ambroxol. Half-life (T½) -15 hours (due to slow reverse diffusion from tissues). Excreted by the kidneys. In chronic renal failure, the excretion of bromhexine metabolites is impaired. With repeated use, Bromhexine can accumulate.

Indications for use

Acute and chronic bronchopulmonary diseases, accompanied by difficulty in expectorating viscous sputum: tracheobronchitis, bronchitis of various etiologies (including those complicated by bronchiectasis), bronchial asthma, pulmonary tuberculosis, pulmonary emphysema, pneumonia (acute and chronic), pneumoconiosis, cystic fibrosis.
Sanitation of the bronchial tree in the preoperative period and during therapeutic and diagnostic intrabronchial manipulations, prevention of accumulation of thick viscous sputum in the bronchi after surgery.

Contraindications

Hypersensitivity to the components of the drug, gastric ulcer and duodenal ulcer, pregnancy, breastfeeding, children under 3 years of age, hereditary lactose intolerance, glucose-galactose malabsorption, lactase deficiency.
Carefully
Use in patients with a history of gastric bleeding, with bronchial diseases accompanied by excessive accumulation of secretions, with a history of episodes of hemoptysis, renal and / or liver failure.

Use during pregnancy and during breastfeeding

Bromhexine crosses the placental barrier and also into breast milk. The drug is contraindicated for use during pregnancy and during breastfeeding.
If necessary, the use of the drug during lactation for the duration of treatment should stop breastfeeding.

Dosage and administration

Inside, regardless of the meal.
Children over 10 years: 24-48 mg (6-12 tablets) divided into 3 doses per day (daily dose - 24-48 mg of bromhexine).
Children from 6 to 10 years old, as well as patients weighing less than 50 kg - 12-24 mg (3-6 tab.) divided into 3 doses per day (daily dose - 12-24 mg of bromhexine).
Children from 3 to 6 years old - 6-12 mg (11/2 -3 tab.) divided into 3 doses per day (daily dose - 6-12 mg of bromhexine).
The therapeutic effect may appear on the 4-6th day of treatment.
The course of treatment is from 4 to 28 days.
Patients with renal insufficiency are prescribed smaller doses or increase the interval between doses.

Side effect

From the gastrointestinal tract: abdominal pain, dyspepsia, incl. nausea, vomiting, exacerbation of peptic ulcer of the stomach and duodenum.
allergic reactions: hypersensitivity reactions (skin rash, itching, angioedema, rhinitis), urticaria, fever, anaphylactic reactions, including anaphylactic shock.
From the skin and subcutaneous tissues: Stevens-Johnson syndrome, Lyell's syndrome, acute generalized exangematous pustulosis.
Other: dizziness, headache, increased activity of "liver" transaminases in the blood serum.

Overdose

The following symptoms are possible: nausea, vomiting, diarrhea and other gastrointestinal disorders.
Treatment: There is no specific antidote. In case of overdose, it is necessary to induce vomiting, and then give the patient liquid (milk or water). Gastric lavage is recommended within 1-2 hours after taking the drug.

Interaction with other drugs

Bromhexine is not prescribed simultaneously with drugs that suppress the cough center (including those containing codeine), as this makes it difficult for thin sputum to pass (accumulation of bronchial secretions in the airways).
Bromhexine promotes the penetration of antibiotics (amoxicillin, ampicillin, erythromycin, cephalexin, oxytetracycline), sulfanilamide drugs into the bronchial secretion in the first 4-5 days of antimicrobial therapy. The combined use of bromhexine with some non-steroidal anti-inflammatory drugs (salicylates, phenylbutazone or butadione) can cause irritation of the gastric mucosa.

special instructions

Very rarely, the occurrence of Stevens-Johnson and Lyell syndromes, which are temporally associated with taking the drug Bromhexine, has been reported. If changes occur on the skin or mucous membranes, stop taking the drug and consult a doctor.
During treatment, it is recommended to consume a sufficient amount of fluid, which supports the secretolytic effect of bromhexine.
In children, treatment should be combined with postural drainage or chest vibration massage, which facilitates the evacuation of secretions from the bronchi.

Influence on the ability to drive vehicles and work with mechanisms

Taking the recommended therapeutic doses (16 mg 3 times a day) does not affect the speed of the patient's psychomotor reactions. In the event of the development of side effects when using the drug, care should be taken when driving vehicles and mechanisms.

Release form

Tablets for children 4 mg.
10, 20, 25, 30, 40 or 50 tablets in a blister pack made of PVC film and printed lacquered aluminum foil.
10, 20, 30, 40, 50 or 100 tablets in polyethylene terephthalate or polypropylene drug jars, sealed with high pressure polyethylene lids with first opening control or with a "push-turn" system or low pressure polyethylene lids with first opening control autopsy.
One jar or 1, 2, 3, 4, 5 or 10 blister packs together with instructions for use are placed in a carton (pack).