Hemomycin instructions for use. Suspension "Hemomycin" for children: instructions for use

Antibiotics - macrolides and azalides.

Composition of Hemomycin

The active substance is azithromycin.

Manufacturers

Hemofarm A.D. (Serbia)

pharmachologic effect

Pharmacological action - antibacterial.

Suppresses protein biosynthesis, slowing down the growth and reproduction of bacteria, at high concentrations a bactericidal effect is possible. Stable in an acidic environment, lipophilic, rapidly absorbed from the gastrointestinal tract.

The maximum concentration is created in 2-3 hours, the half-life is 68 hours.

A stable plasma level is reached after 5-7 days.

It easily passes histohematic barriers and enters the tissues.

Concentrations in tissues and cells are 10-50 times higher than in plasma, and in the focus of infection - 24-34% higher than in healthy tissues.

A high level (antibacterial) persists in the tissues for 5-7 days after the last injection.

It is excreted in the bile (50%) unchanged and in the urine (6%). The spectrum of action is wide and includes gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, streptococci of groups C, F, G, Streptococcus viridans ), except for those resistant to erythromycin, and gram-negative (Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Campylobacter jejuni, Legionella pneumophila, Neisseria gonorrhoeae, Gardnerella vaginalis) microorganisms, anaerobes (Bacteroides bivius, Peptostreptococcus spp., P eptococcus, Clostridium perfringens) , chlamydia (Chlamydia trachomatis, Chlamydia pneumoniae), mycobacteria (Mycobacteria avium complex), mycoplasma (Mycoplasma pneumoniae), ureoplasma (Ureaplasma urealyticum), spirochetes (Treponema pallidum, Borrelia burgdorferi).

Side effects of Hemomycin

Nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea, melena, cholestatic jaundice, chest pain, palpitations, weakness, drowsiness, headache, dizziness, nephritis, vaginitis, candidiasis, neutropenia or neutrophilia, pseudomembranous colitis, photosensitivity, rash , angioedema, eosinophilia; in children, in addition, hyperkinesia, agitation, nervousness, insomnia, conjunctivitis.

Indications for use

Infections of the upper and lower respiratory tract (streptococcal pharyngitis and tonsillitis, bacterial exacerbation of chronic obstructive pneumonia, interstitial and alveolar pneumonia, bacterial bronchitis), ENT organs (otitis media, laryngitis and sinusitis), genitourinary system (urethritis and cervicitis), skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses), chronic stage of erythema migrans (Lyme disease).

Contraindications Hemomycin

Hypersensitivity to macrolides, severe liver dysfunction, pregnancy, lactation.

Method of application and dosage

The drug is taken orally 1 time / 1 hour before meals or 2 hours after meals, because. when taken simultaneously with food, the absorption of azithromycin decreases.

In case of missing one dose of the drug, it should be taken as soon as possible, and subsequent doses should be taken at intervals of 24 hours.

Overdose

No information.

Interaction

special instructions

Use with caution in severe violations of the liver, kidneys, cardiac arrhythmias.

After discontinuation of treatment, hypersensitivity reactions may persist in some patients, which requires specific therapy under medical supervision.

Storage conditions

List B.

Store in a dry, dark place at room temperature, out of the reach of children.

Every mother does everything possible to ensure that her child is healthy and happy. But, unfortunately, this is not always possible. Often the presence of a child with a runny nose in kindergarten can cause a cold in your crumbs. The drug market today is full of various offers. But the choice of medicine should always be approached very carefully. If we are talking about antibiotics, then your care should be maximum.

Today I want to find out what are the main indications and spectrum of action of the antibiotic Hemomycin. It is quite popular among mothers. Let's find out its composition, evaluate the side effects and draw conclusions whether it really is that good. Or maybe it's better to pick up some kind of analogue. The price of Hemomycin suspension 200 mg for children varies from 126 rubles or 63 hryvnias. Of course, there are cheaper and more expensive drugs that are similar in composition. But for now, let's find out how effective Hemomycin is.

Hemomycin is produced in four types:

• Capsules. Outwardly, they have a hard gelatinous light blue shell, and inside - a white powder. There are 6 capsules in a blister, 1 blister in a pack.

• Pills. Film-coated, gray-blue, biconvex. There are usually 3 tablets in a blister, and 1 blister in a carton.

• The powder from which the suspension is made. Its color is white or very close to it, with a fruity smell. The package contains a dark bottle, the weight of the powder is 10-12 g. A measuring spoon is included.

• Special form of the drug for injection.

Compound

The main active ingredient is azithromycin in the form of a dihydrate. Auxiliary components are also added - corn starch, fruit flavors, sodium saccharin, calcium carbonate, sorbitol, etc.

Operating principle

Hemomycin is a broad-spectrum bactericidal antibiotic. Azithromycin inhibits protein synthesis at the cellular level in pathogenic microorganisms. As a result, it helps block the growth of many bacteria.

It is active against aerobic Gram-positive bacteria. These include streptococci, gonococci, staphylococci, listeria. It is also active against aerobic gram-negative bacteria, anaerobic bacteria. This drug is active against intracellular microorganisms - chlamydia trachomatis, mycoplasma, ureaplasma, etc. Improvement is observed in patients whose cause of illness was obligate intrapulmonary microorganisms, for example, mycoplasmas, chlamydia, legionella.

The drug does not act on gram-positive bacteria that are resistant to erythromycin.

Indications

Inflammatory and infectious diseases caused by microorganisms that are sensitive to this drug:

• Infections of the ENT organs and upper respiratory tract. These include sinusitis, otitis media, and tonsillitis.

• Infections of the urogenital tract.
• Infections of the skin and soft tissues, such as impetigo, secondarily infected dermatitis.
• Scarlet fever.
• Diseases of the intestines and duodenum caused by the bacterium Helicobacter pylori.
• Lower respiratory tract infections (bronchitis, bacterial pneumonia).
• Treatment in the early stages of Lyme disease.

From what age can be allowed to use: You can use Hemomycin from six months of age.

Contraindications in children

• Hypersensitivity to macrolide antibiotics.
• Renal and liver failure.
• Age category up to 12 years (for capsules and tablets).
• Children under the age of 12 months (for a solution with a concentration of 200 mg / 5 ml).
• Age up to 6 months (for a suspension with a concentration of 100 mg / 5 ml).
• This drug should be used with caution in pregnant women, with arrhythmias, in children with impaired renal and hepatic functions.

Adverse reactions

• Allergic: itching, urticaria, conjunctivitis.
• In the central nervous system: insomnia, headache, anxiety, sleep disturbance, neurosis.
• In the digestive system: stomach pain, nausea, gastritis, flatulence, vomiting, cholestatic jaundice, candidiasis of the oral mucosa, elevated liver enzymes, diarrhea or constipation, change in taste.
• From the urinary and reproductive system: nephritis, vaginal candidiasis.
• In the cardiovascular system: chest pain, palpitations.

Hemomycin 250: instructions for use and dosage for children

The instruction implies the use of this medicine 1 time per day in between meals. Ideally, 1 hour before or 2 hours after a meal. Such requirements were formed for the reason that the active ingredients of the antibiotic are poorly absorbed with food.

Capsules Hemomycin 250

The recommended dosage of an antibiotic for children over 12 years of age with infections of the lower and upper respiratory tract, as well as soft tissues and skin, is 10 mg / kg 1 time per day. The recommended duration of treatment is 3 days. Given the characteristics of the course of the disease, it is worth relying on a doctor's prescription.

Hemomycin tablets

Can be prescribed to adults and children over 12 years of age with infections of the lower and upper respiratory tract at a dosage of 500 mg / day for 3 days.

• In acute uncomplicated urethritis, the doctor may prescribe the drug once at a dose of 1 g.
• In diseases of the stomach caused by the bacterium Helicobacter pylari, 1 g per day is prescribed for 3 days.

Instructions for use of Hemomycin suspension for children 200 mg / 5 ml and 100 mg / 5 ml

The suspension is prepared as follows: First you need to prepare the water - boil it and cool it. Pour prepared water into the bottle (or you can use distilled water) to the desired mark and shake thoroughly until smooth. Shake the suspension before each use.

You can store the diluted medicine at room temperature for up to 5 days. The instruction also asks to pay attention to the fact that after using the medicine, the baby needs to be given a few sips of water or other liquid in order to completely wash it off the oral cavity, and it gets inside.

Overdose

Overdose symptoms can be: temporary hearing loss, nausea, vomiting, diarrhea.
In this case, it is necessary to carry out gastric lavage and symptomatic therapy.

How it interacts with other drugs

• With the simultaneous use of magnesium and aluminum-containing with Hemomycin, absorption of azithromycin is observed.
• The process of assimilation of azithromycin is slowed down by ethanol and food.
• The combined use of digoxin and azithromycin significantly increases the concentration of the former.
• There is a struggle of the drug with lincosamides, cephalosporins, antibiotics of the penicillin group.
• The main component of the antibiotic azithromycin is incompatible with heparin.
• But it enhances the action of tetracyclines, sulfonamides, streptomycin.

Terms of storage and sale

The drug should be stored at a temperature of 15 ° to 25 °, protected from children and direct sunlight. The shelf life is 2 years.

The drug is sold only by prescription of the attending physician.

Reviews of Hemomycin suspension for children

Most often on pharmaceutical sites you can find positive reviews about the drug. This helps to form a good assessment about its effectiveness and quality. Most often, young parents write about malfunctions in the gastrointestinal tract, and this is its only disadvantage. Therefore, if any symptoms appear, you should immediately contact your doctor to adjust the dosage or even change the medication.

Jeanne:

On the 4th day of taking the antibiotic, there was no improvement in the child. Sometimes they write that the effect can come after the end of taking the whole course, we did not wait for it. We went to the pediatrician for a new appointment, wrote out injections. Based on my personal experience, I can say that this antibiotic does not help everyone.

Natalia:

My daughter refused to take Hemomycin, despite the fact that she diluted it with tea and compote, constantly spitting it out. As a result, she did not drink the full portion. But I can note that in combination with other drugs, there was an effect, and the cough receded.

Alina:

Helped my child repeatedly in the treatment of scarlet fever, bronchitis and purulent tonsillitis. In addition, an acceptable price, and you need to use only 3 days, and then, 1 time per day. We didn't have any side effects. I can safely recommend, only after a preliminary consultation with a doctor. One piece of advice: if you are offered Sumamed in a pharmacy, then know that there is no difference in efficiency, but the price of the latter is almost twice as high.

Victoria:

A very effective drug. We drank it twice and were satisfied, as it did not cause side effects, and the improvement came by the middle of the second day. And yes, it's reasonably priced.

Irina:

The downside of this antibiotic for me is that after shaking, the agent remains on the walls, and after that it does not reach the desired mark. In this regard, it turns out that only half the dose remains by the last dose. And given that the course of admission is small, I'm worried that its action will not be enough to defeat the viruses. But during the reception he won a cold, only a slight cough and runny nose remained. Its plus is that Hemomycin does not affect the intestines, as happens when taking antibiotics.

Analogues

• Suprax. This is a potent antibiotic of the third generation, it is allowed to use it from 6 months. It has a fairly wide range of action. But it is prescribed by doctors only when less powerful drugs do not cope. Its price is an order of magnitude higher than that of Hemomycin. But, at the same time, this antibiotic copes with any kind of disease, including —angina in children—.
• Zinnat. It is allowed to be used from the age of three months. This drug acts selectively on the causative agent of infections: for someone more strongly, for someone less, it may not work at all.
• Amoxicillin. This drug is prescribed from any age. However, it is not very effective in the fight against certain types of staphylococci and a number of other viruses, but this antibiotic is most often prescribed - an antibiotic for bronchitis in children -.

The analogues of Hemomycin for the active substance are:

• Sumamed- is sold both in tablets and capsules, and in granules for dilution with water and preparation of a suspension. Recommended for use from 6 months. As for the price, it is slightly inferior to Hemomycin.
• Ecomed. This antibiotic is also available in three of the same forms as Sumamed or Hemomycin. Can be recommended for use from 6 months.

Features of the use of antibiotics in children

There are a few rules to follow when using them:

• you cannot decide on their appointment or termination of use on your own, this must be discussed with your doctor;
• you must strictly follow the indicated dosage;
• you can not stop using the drug ahead of time, even if you see slight improvements;
• provide the baby with bed rest;

• regularly ventilate the room;
• carry out wet cleaning;
• eliminate spicy, fried, salty foods from his diet.

After taking antibiotics, you need to help restore the intestinal microflora and immunity with the help of drugs with live bacteria - probiotics. Usually the body needs 5-10 days to bounce back.

Video review of the drug

Maintaining the health of your child is one of the most important tasks of every parent. Now in the pharmaceutical market you can find a huge variety of drugs. But how to understand which of them is effective, and which will really help your baby? I suggest watching a video in which a specialist answers important questions and talks about all the intricacies of taking a drug such as Hemomycin.

A very important point in the formation of health and immunity in a baby is not only the correct lifestyle and habits, but also the period of his intrauterine life. After all, the fact that the body was saturated with essential vitamins and minerals also plays a significant role. Many doctors recommend abstaining from citrus fruits during pregnancy, as they are a food that can cause —-allergies during this period—.

Of course, 99% of mothers will not under any circumstances risk their health and the health of their baby. However, I can say with absolute certainty that if you feel an irresistible thirst to eat a product, do it. Perhaps this is what your baby needs right now, and will play an important role in strengthening the health and immunity of your crumbs.

Share your observations in the use of Hemomycin. How did your baby react to taking it, were there any side effects - tell us about it in the comments on the site! And I wish you and your baby good health!

Excipients: anhydrous lactose - 163.6 mg * (151.57 mg), corn starch - 47 mg, sodium lauryl sulfate - 0.94 mg, magnesium stearate - 8.46 mg.

* The amount of anhydrous lactose depends on the activity of the active substance.

Shell composition: titanium dioxide (E171) - 1.44 mg, patent blue dye V (E131) - 0.0164 mg, gelatin - up to 96 mg.

6 pcs. - blisters (1) - packs of cardboard.

Film-coated tablets greyish-blue, round, biconvex.

Excipients: microcrystalline silicate cellulose - 69 mg, microcrystalline cellulose - 57 mg, sodium carboxymethyl starch (type A) - 46 mg, - 24 mg, magnesium stearate - 10 mg, talc - 10 mg, colloidal silicon dioxide - 1 mg.

Shell composition: titanium dioxide - 10.58 mg, talc - 9.57 mg, copovidone - 4.95 mg, ethylcellulose - 4.95 mg, macrogol 6000 - 1.32 mg, (indigotin) E132 - 1.22 mg, lacquer dye green 8% (indigocarmine (indigotine) E132, quinoline yellow E104) - 0.41 mg.

3 pcs. - blisters (1) - packs of cardboard.

Excipients: xanthan gum - 20.846 mg, sodium saccharinate - 4.134 mg, calcium carbonate - 162.503 mg, colloidal silicon dioxide - 26.008 mg, anhydrous sodium phosphate - 17.259 mg, sorbitol - 2145.682 mg, apple flavor - 3.303 mg, strawberry flavor - 8 .159 mg, cherry flavor - 12.096 mg.

11.43 g - dark glass bottles (1) complete with a measuring spoon (volume 5 ml, with a risk for a volume of 2.5 ml) - packs of cardboard.

Powder for suspension for oral administration white or almost white, with a fruity odor; the prepared suspension is almost white in color, with a fruity odor.

Excipients: xanthan gum, sodium saccharinate, calcium carbonate, colloidal silicon dioxide, anhydrous sodium phosphate, sorbitol, apple flavor, strawberry flavor, cherry flavor.

10 g - dark glass bottles (1) complete with a measuring spoon (volume 5 ml, with a risk for a volume of 2.5 ml) - packs of cardboard.

pharmachologic effect

Broad spectrum antibiotic. Azithromycin is a representative of a subgroup of macrolide antibiotics - azalides. In high concentrations, it has a bactericidal effect.

Pharmacokinetics

Suction

Azithromycin is rapidly absorbed from the gastrointestinal tract, due to its stability in an acidic environment and lipophilicity. After oral administration of Hemomycin at a dose of 500 mg Cmax of azithromycin in the blood is reached after 2.5-2.96 hours and is 0.4 mg / l. Bioavailability is 37%.

Distribution

Azithromycin penetrates well into the respiratory tract, organs and tissues of the urogenital tract, into the prostate gland, into the skin and soft tissues. High concentration in tissues (10-50 times higher than in blood plasma) and long T 1/2 are due to the low binding of azithromycin to plasma proteins, as well as its ability to penetrate eukaryotic cells and concentrate in a low pH environment surrounding lysosomes . This, in turn, determines the large apparent V d (31.1 l/kg) and high plasma clearance. The ability of azithromycin to accumulate predominantly in lysosomes is especially important for the elimination of intracellular pathogens. It has been proven that phagocytes deliver azithromycin to the sites of infection, where it is released during phagocytosis. The concentration of azithromycin in the foci of infection is significantly higher than in healthy tissues (on average by 24-34%) and correlates with the degree of inflammatory edema. Despite the high concentration in phagocytes, azithromycin does not significantly affect their function.

Azithromycin remains at bactericidal concentrations in the inflammatory focus for 5-7 days after the last dose, which made it possible to develop short (3-day and 5-day) courses of treatment.

Metabolism

In the liver, azithromycin is demethylated, the resulting metabolites are not active.

breeding

Removal of azithromycin from blood plasma takes place in 2 stages: T 1/2 is 14-20 hours in the range from 8 to 24 hours after taking the drug and 41 hours - in the range from 24 to 72 hours, which allows you to use the drug 1 time / day.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, otitis media);
• scarlet fever;
• infections of the lower respiratory tract (bacterial, including those caused by atypical pathogens, pneumonia, bronchitis);
• infections of the urogenital tract (uncomplicated urethritis and / or cervicitis);
• infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses);
• Lyme disease (borreliosis) for the treatment of the initial stage (erythema migrans);
• diseases of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy) (for tablets and capsules).

Contraindications

• liver failure;
• kidney failure;
• children's age up to 12 years (for capsules and tablets);
• children's age up to 12 months (for a suspension of 200 mg / 5 ml);
• children's age up to 6 months (for a suspension of 100 mg / 5 ml);
• hypersensitivity to macrolide antibiotics.

WITH caution the drug should be prescribed during pregnancy, with arrhythmias (ventricular arrhythmias and prolongation of the QT interval are possible), children with severe impaired liver or kidney function.

Dosage

The drug is taken orally 1 time / day 1 hour before meals or 2 hours after meals, because. when taken simultaneously with food, the absorption of azithromycin decreases.

In case of missing one dose of the drug, it should be taken as soon as possible, and subsequent doses should be taken at intervals of 24 hours.

Capsules

Adults at Hemomycin is prescribed 500 mg (2 caps.) per day for 3 days; course dose - 1.5 g.

At appoint 1 g (4 caps.) on the 1st day, then - 500 mg (2 caps.) daily from 2 to 5 days; course dose - 3 g.

At appoint once 1 g (4 caps.).

At Lyme disease(borreliosis) for the treatment of the initial stage (erythema migrans) is prescribed 1 g (4 caps.) on the 1st day and 500 mg (2 caps.) daily from 2 to 5 days (course dose - 3 g).

At , appoint 1 g (4 caps.) per day for 3 days as part of a combined anti-Helicobacter therapy.

Children over 12 years old at infections of the upper and lower respiratory tract, skin and soft tissues the drug is prescribed at the rate of 10 mg / kg 1 time / day for 3 days (course dose - 30 mg / kg) or on the first day - 10 mg / kg, then 4 days - 5-10 mg / kg / day.

At treatment of erythema migrans- 20 mg/kg on the first day and 10 mg/kg from days 2 to 5.

Pills

Adults and children over 12 years old at infections of the upper and lower respiratory tract appoint 500 mg / day for 3 days; course dose - 1.5 g.

At skin and soft tissue infections appoint 1 g / day on the first day, then 500 mg daily from 2 to 5 days; course dose - 3 g.

At acute uncomplicated urethritis or cervicitis administered as a single dose of 1 g.

At Lyme disease(borreliosis) for the treatment of the initial stage (erythema migrans), the drug is prescribed at a dose of 1 g on the 1st day and 500 mg daily from 2 to 5 days; course dose - 3 g.

At diseases of the stomach and duodenum associated with Helicobacter pylori, appoint 1 g / day for 3 days as part of a combined anti-Helicobacter therapy.

Suspension 200 mg/5 ml and 100 mg/5 ml

At children over 12 months apply a suspension of 200 mg / 5 ml, children older than 6 months- suspension 100 mg/5 ml.

children at upper and lower respiratory tract infections, skin and soft tissue infections(with the exception of chronic migratory erythema) Hemomycin in the form of a suspension is prescribed at the rate of 10 mg/kg body weight 1 time/day for 3 days (course dose - 30 mg/kg).

Adults at infections of the upper and lower respiratory tract appoint 500 mg 1 time / day for 3 days; course dose - 1.5 g.

At infections of the urogenital tract the drug is prescribed adults at a dose of 1 g once; children under 8 years of age with a body weight of more than 45 kg- 10 mg/kg once.

At chronic erythema migrans appoint 1 time / day for 5 days: adults- 1 g / day on the 1st day for 1 dose, then 500 mg / day daily from 2 to 5 days, course dose - 3 g; children- on the 1st day at a dose of 20 mg / kg of body weight, then from 2 to 5 days - 10 mg / kg of body weight.

1st day

2-5th day

Suspension preparation rules

Water (distilled or boiled and cooled) is gradually added to the vial containing the powder to the mark. The contents of the vial are thoroughly shaken until a homogeneous suspension is obtained.

If the level of the prepared suspension is below the mark on the vial label, re-add water to the mark and shake.

The prepared suspension is stable at room temperature for 5 days.

The suspension should be shaken before use.

Immediately after taking the suspension, the child should be allowed to drink a few sips of liquid (water, tea) in order to wash off and swallow the suspension remaining in the oral cavity.

Side effects

From the digestive system: diarrhea (5%), nausea (3%), abdominal pain (3%); 1% or less - dyspepsia, vomiting, flatulence, melena, cholestatic jaundice, increased activity of liver enzymes, in children - constipation, anorexia, gastritis.

From the side of the cardiovascular system: palpitations, chest pain (1% or less).

From the side of the central nervous system: dizziness, headache, vertigo, drowsiness; in children - headache (in the treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbance (1% or less).

From the reproductive system: vaginal candidiasis.

From the urinary system: jade (1% or less).

Allergic reactions: rash, angioedema; in children - conjunctivitis, itching, urticaria.

Others: increased fatigue, photosensitivity.

Overdose

Symptoms: nausea, temporary hearing loss, vomiting, diarrhea.

Treatment: gastric lavage, symptomatic therapy.

drug interaction

With the simultaneous use of Hemomycin and antacids (aluminum- and magnesium-containing), the absorption of azithromycin slows down.

Ethanol and food slow down and reduce the absorption of azithromycin.

With the joint appointment of warfarin and azithromycin (at usual doses), no change in prothrombin time was detected, however, given that the interaction of macrolides and warfarin may increase the anticoagulant effect, patients need careful monitoring of prothrombin time.

The combined use of azithromycin and digoxin increases the concentration of the latter.

With the simultaneous use of azithromycin with ergotamine and dihydroergotamine, there is an increase in the toxic effect of the latter (vasospasm, dysesthesia).

Co-administration of triazolam and azithromycin reduces clearance and enhances the pharmacological action of triazolam.

Azithromycin slows down the excretion and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, as well as drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, disopyramide, bromocriptine, phenytoin, oral hypoglycem agents, theophylline and other xanthine derivatives) - due to the inhibition of microsomal oxidation in hepatocytes by azithromycin.

Lincosamines weaken the effectiveness of azithromycin, while tetracycline and chloramphenicol increase it.

Pharmaceutical interaction

Azithromycin is pharmaceutically incompatible with heparin.

special instructions

Do not take the drug during meals.

After discontinuation of treatment in some patients, hypersensitivity reactions may persist, which requires specific therapy and medical monitoring.

Pregnancy and lactation

During pregnancy, Hemomycin is prescribed only when the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

If necessary, the use of the drug during lactation should decide whether to stop breastfeeding for the duration of the drug.

Care must be taken when prescribing the drug to patients with severe liver dysfunction (especially children). Contraindicated in liver failure.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

List B. The drug should be stored out of the reach of children, protected from light, at a temperature of 15 ° to 25 ° C. Shelf life for tablets and powder - 2 years; for capsules - 3 years.

The Serbian drug Hemomycin ® is a broad-spectrum antibiotic from the group. These antibiotics today are one of the most effective and low-toxic drugs for the treatment of various infections of bacterial origin. In addition, the indisputable advantage of azalides is a short course of antibiotic therapy and the ability to take them only once a day.

Despite the fact that the release of this drug in pharmacies is over-the-counter, it cannot be used without a medical recommendation. Any potent medicines, including antibacterial ones, require a responsible and qualified approach to their prescription. The description and instructions for the medicine below are for informational purposes only and are not a guide to self-medication.

Prescription for Hemomycin ® in Latin

Rp.: Hemomycini 0.5
D.t.d. No. 3
S. 1 tablet once a day.

Composition Hemomycin ®

The active substance is a fifteen-membered macrolide antibiotic of the azalide subclass azithromycin. When the pathogen enters the cell, it acts bacteriostatically, inhibiting the process of protein synthesis and, accordingly, preventing the growth and development of the pathogen. At an increased dosage, it already has a bactericidal effect. The following bacteria are susceptible to it:

It should be borne in mind that microorganisms that are immune to the founder of the class of macrolides, erythromycin, are also resistant to azalides. Azithromycin is absorbed from the gastrointestinal tract very quickly, and its bioavailability is within 40%. It binds slightly to plasma proteins, accumulating mainly in soft tissues, lysosomes of the respiratory and urinary organs, and skin. This explains its therapeutic effect in the treatment of infections provoked by intracellular pathogens.

Accumulating in the foci of infection in high concentrations, the drug is subsequently released over a long period of time, which allows it to be taken in short courses with 24-hour intervals between doses. Metabolized in liver cells to inactive compounds, excreted in urine and feces.

Release form

The owner of the registration certificate and the manufacturer of Hemomycin ® is the Serbian pharmaceutical concern Hemofarm A.D. ® currently produces several dosage forms that allow the use of an antibiotic for the treatment of patients of different ages:

• Capsules 250 mg, in which auxiliary ingredients are corn starch, lactose, sodium lauryl sulfate, magnesium stearate and gelatin shell components. 6 pieces are packed in cardboard boxes.
• Film-coated tablets containing 500 mg antibiotic trihydrate. The formative compounds are silicate and conventional MCC, sodium carboxymethyl starch, anhydrous silica, povidone and talc. Packed 3 pieces in a blister and a pack.
• The powder from which the suspension is prepared by adding water is Hemomycin ® for children. This dosage form may contain 100 or 200 mg of the active ingredient in 5 ml of the finished product. The composition contains sweeteners and flavors, the packaging is glass bottles. The kit includes a spoon, with which it is convenient to give medicine to a child in accordance with his body weight.
• Lyophilisate 500 mg in vials - a substance for the preparation of a solution that is used parenterally (intravenous drip) in a hospital.

The cost varies between 110-300 rubles per pack, depending on the specific dosage form (the cheapest option is a suspension).

What helps Hemomycin ®

Taking into account the spectrum of antimicrobial action, medications based on this antibiotic are successfully used to treat many bacterial infections. Azithromycin is the drug of choice for some STDs (chancre, chlamydia,), as well as a backup option in case of other sexually transmitted diseases. It is also effective in case of inflammations of the lower and upper respiratory tract caused by susceptible types of microorganisms.

Since the drug is practically harmless, does not require long-term treatment and does not provoke negative responses of the body, it is often used in pediatric practice. In addition, the suspension has a pleasant taste, which facilitates the treatment of babies. For example, Hemomycin ® with angina already on the second day of antibiotic therapy significantly reduces the severity of symptoms.

The drug is also used for the complex eradication of the causative agent of peptic ulcer of the duodenum and stomach - the bacterium Helicobacter pylori. In this case, a tablet or encapsulated dosage form is prescribed. And the ability of the antibiotic to accumulate in soft tissues allows it to be successfully used for various lesions of the skin, fiber and muscles.

Indications and contraindications of Hemomycin ®

The spectrum and mechanism of antimicrobial action are the basis for prescribing the drug in the development of the following infectious and inflammatory processes:

• all kinds, and;
• uncomplicated and urethritis (including);
• dermatoses resulting from secondary infection, impetigo;
• tick-borne borreliosis in the initial stage;
• associated with ulcerative lesions of the gastrointestinal tract.

Due to demethylation in the liver and excretion through the kidneys, the active substance of Hemomycin ® is contraindicated in case of insufficiency of these organs. It is also impossible to use any forms of the drug in case of intolerance to any components in their composition. Pregnant women and patients with arrhythmia are prescribed carefully, taking into account possible risks.

It is also required to observe age restrictions when using an antibiotic. Tablets and capsules are prescribed only after reaching 12 years. In addition, the instructions for use for children of Hemomycin ® suspension indicate that a drug containing 200 mg of azithromycin in 5 ml should not be given to a child under one year old, and with a concentration of 100 mg - earlier than 6 months of age.

Pregnancy

According to the doctor's prescription, the drug can be taken during pregnancy in cases where the benefit to the mother outweighs the possible risk to the baby.

Dosages for tablets, capsules and lyophilisate

Oral dosage forms, due to the characteristics of absorption, should be taken strictly on an empty stomach, since food in the gastrointestinal tract makes absorption difficult. The best option is an hour before or two hours after a meal, preferably in the evening. The following antibiotic regimens are usually prescribed:

• Three-day treatment of inflammation of the respiratory tract and ENT organs by taking 500 mg of the drug every 24 hours (that is, the course dose is 1.5 g).
• Cervicitis and urethritis, provoked by gonococci and intracellular pathogens, are treated with a single use of one gram of an antibiotic.
• Therapy of borreliosis and skin infections requires a five-day treatment with a total course dose of 3 grams. On the first day, you need to take two tablets of 500 mg, and then one every 24 hours.
• Combination therapy for Helicobacter-associated inflammation consists in the use of 3000 mg of the drug, 1000 times a day.

If the interval between taking tablets (capsules) has been exceeded, the next dose should be taken immediately and subsequently adhere to the new schedule.

The lyophilisate instructions for use Hemomycin ® recommends that it be administered strictly intravenously and very slowly (over the course of an hour by drip) in a hospital setting. The solution is prepared in stages: first, water for injection (4.8 ml) is added to the antibiotic vial, and after the substance is completely dissolved, the drug is brought to the required concentration with dextrose, Ringer or physiological solutions. So, to obtain a dose of 2 mg per ml, 250 milliliters of solvent are added, and 1 mg / ml - 500.

Severe forms of community-acquired pneumonia and inflammatory processes in the pelvic organs are treated with infusions of the antibiotic Hemomycin ® according to the instructions for the first two days (one infusion of 500 mg of the active substance per day). Then the patient is transferred to oral dosage forms: 0.5 grams for at least a week daily for pneumonia and 0.25 in case of urogenital infections. Moderate insufficiency of the liver and kidneys does not require correction of the daily and course dose (creatinine clearance should exceed 40 milliliters per minute). The infusion method of drug administration is not used for the treatment of children and adolescents under 16.

Hemomycin ® suspension for children: dilution and dosage

This medication is taken in the same way as tablets and capsules: on an empty stomach and only once a day. Before the first use, the powder is diluted with distilled or boiled water, which must be gradually added to the bottle until a special mark is applied to it. The choice of one of the antibiotic concentration options (100 or 200 mg / 5 ml) is made by the pediatrician in accordance with age restrictions and the nature of the disease. He also prescribes the optimal dose, taking into account the body weight of the child.

For any inflammatory processes caused by susceptible pathogens, children are shown to be given 10 mg of an antibiotic per day for every kilogram of weight. For a suspension containing 200 mg of azithromycin in 5 ml, the recommended doses are as follows:

• a child weighing 10 to 14 kg should take 2.5 ml of medication per day;
• with a weight of 15-25 kilograms - 5 milliliters;
• 26-35 - up to 7.5 (one and a half measured or teaspoons);
• children weighing 36 to 45 kg are given 10 ml of suspension;
• weighing over 45 kilograms are given "adult" doses.

For a drug with an antibiotic concentration of 100 mg / 5 ml, the dosage is doubled. Before the first and each subsequent dose, the bottle is thoroughly shaken until a homogeneous substance is obtained. The prepared product is stored at room temperature for no more than 5 days.

Side effects

Any dosage form of Hemomycin ® for adults and children is of low toxicity, however, the development of negative reactions of the body in some cases is possible. There are such phenomena as nausea (no more than 5% of cases), epigastric pain, and extremely rarely - vomiting, jaundice, activation of liver enzymes, gastritis and anorexia. Tachycardia, headache, drowsiness, anxiety, hyperkinesia, nephritis, photosensitivity, candidiasis, allergies (in children in the form of conjunctivitis or urticaria) may occur. The listed side effects are recorded in less than 1% of patients.

In this article, you can read the instructions for using the drug Hemomycin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of the antibiotic Hemomycin in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Hemomycin analogues in the presence of existing structural analogues. Use for the treatment of tonsillitis, pneumonia and other infectious diseases in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Hemomycin- a broad-spectrum antibiotic. Azithromycin (active ingredient of the drug Hemomycin) is a representative of a subgroup of macrolide antibiotics - azalides. In high concentrations, it has a bactericidal effect.

Hemomycin is active against aerobic gram-positive and gram-negative bacteria, as well as anaerobic bacteria.

The drug is active against intracellular microorganisms: Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Borrelia burgdorferi, as well as against Treponema pallidum.

Gram-positive bacteria resistant to erythromycin are resistant to the drug.

Compound

Azithromycin (in the form of a dihydrate) + excipients.

Pharmacokinetics

Hemomycin is rapidly absorbed from the gastrointestinal tract due to its acid stability and lipophilicity. Bioavailability is 37%. Azithromycin penetrates well into the respiratory tract, organs and tissues of the urogenital tract, into the prostate gland, into the skin and soft tissues. The ability of azithromycin to accumulate predominantly in lysosomes is especially important for the elimination of intracellular pathogens. It has been proven that phagocytes deliver azithromycin to the sites of infection, where it is released during phagocytosis. The concentration of azithromycin in the foci of infection is significantly higher than in healthy tissues (on average by 24-34%) and correlates with the degree of inflammatory edema. Despite the high concentration in phagocytes, azithromycin does not significantly affect their function. Azithromycin remains at bactericidal concentrations in the inflammatory focus for 5-7 days after the last dose, which made it possible to develop short (3-day and 5-day) courses of treatment.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• infections of the upper respiratory tract and ENT organs (tonsillitis, sinusitis, tonsillitis, otitis media);
• scarlet fever;
• infections of the lower respiratory tract (bacterial and atypical pneumonia, bronchitis);
• infections of the urogenital tract (uncomplicated urethritis and / or cervicitis);
• infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses);
• Lyme disease (borreliosis) for the treatment of the initial stage (erythema migrans);
• diseases of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy) (for tablets).

Release form

Powder for suspension for oral administration 100 mg and 200 mg (sometimes erroneously called syrup).

Capsules 250 mg.

Film-coated tablets 100 mg.

Lyophilisate for solution for infusion (injections in ampoules for injection).

Instructions for use and dosage

The drug is taken orally 1 time per day 1 hour before meals or 2 hours after meals, because. when taken simultaneously with food, the absorption of azithromycin decreases.

In case of missing one dose of the drug, it should be taken as soon as possible, and subsequent doses should be taken at intervals of 24 hours.

Capsules

For adults with infections of the upper and lower respiratory tract, Hemomycin is prescribed 500 mg (2 capsules) per day for 3 days; course dose - 1.5 g.

For infections of the skin and soft tissues, 1 g (4 capsules) is prescribed on the 1st day, then 500 mg (2 capsules) daily from 2 to 5 days; course dose - 3 g.

In acute uncomplicated urethritis or cervicitis, 1 g (4 capsules) is prescribed once.

In Lyme disease (borreliosis) for the treatment of the initial stage (erythema migrans), 1 g (4 capsules) is prescribed on the 1st day and 500 mg (2 capsules) daily from 2 to 5 days (course dose - 3 g) .

In diseases of the stomach and duodenum associated with Helicobacter pylori, 1 g (4 capsules) per day for 3 days is prescribed as part of a combined anti-Helicobacter therapy.

For children over 12 years of age with infections of the upper and lower respiratory tract, skin and soft tissues, the drug is prescribed at the rate of 10 mg / kg 1 time per day for 3 days (course dose - 30 mg / kg) or on the first day - 10 mg / day kg, then 4 days - 5-10 mg / kg per day.

In the treatment of erythema migrans - 20 mg / kg on the first day and 10 mg / kg from 2 to 5 days.

Pills

Adults and children over 12 years of age with infections of the upper and lower respiratory tract are prescribed 500 mg per day for 3 days; course dose - 1.5 g.

For infections of the skin and soft tissues, 1 g per day is prescribed on the first day, then 500 mg daily from the 2nd to the 5th day; course dose - 3 g.

In acute uncomplicated urethritis or cervicitis, a single dose of 1 g is prescribed.

In Lyme disease (borreliosis) for the treatment of the initial stage (erythema migrans), the drug is prescribed at a dose of 1 g on the 1st day and 500 mg daily from 2 to 5 days; course dose - 3 g.

In diseases of the stomach and duodenum associated with Helicobacter pylori, 1 g per day for 3 days is prescribed as part of a combined anti-Helicobacter therapy.

Suspension

In children older than 12 months, a 200 mg suspension is used, in children older than 6 months, a 100 mg suspension.

For children with infections of the upper and lower respiratory tract, infections of the skin and soft tissues (with the exception of chronic migratory erythema), Hemomycin in the form of a suspension is prescribed at the rate of 10 mg / kg of body weight 1 time per day for 3 days (course dose - 30 mg / kg).

Adults are prescribed 500 mg 1 time per day for 3 days; course dose - 1.5 g.

For infections of the urogenital tract, the drug is prescribed to adults at a dose of 1 g once.

In chronic migrating erythema, it is prescribed 1 time per day for 5 days: on the 1st day at a dose of 20 mg / kg of body weight, then from 2 to 5 days - 10 mg / kg of body weight.

Suspension preparation rules

Water (distilled or boiled and cooled) is gradually added to the vial containing the powder to the mark. The contents of the vial are thoroughly shaken until a homogeneous suspension is obtained. If the level of the prepared suspension is below the mark on the vial label, re-add water to the mark and shake.

The prepared suspension is stable at room temperature for 5 days.

The suspension should be shaken before use.

Immediately after taking the suspension, the child should be allowed to drink a few sips of liquid (water, tea) in order to wash off and swallow the suspension remaining in the oral cavity.

Ampoules

The drug should be used only in stationary medical institutions. Recommended doses for intravenous administration of Chemomycin in the treatment of adults and patients over 16 years of age with the following diseases:

Community-acquired pneumonia (CAP)

500 mg once a day intravenously for at least 2 days. In / in the introduction should be replaced by subsequent oral administration of azithromycin in the form of a single daily dose of 500 mg until the completion of the 7-10 day total course of treatment.

Infectious and inflammatory diseases of the pelvic organs

500 mg once a day intravenously for at least 2 days. In / in the introduction should be replaced by subsequent oral administration of azithromycin in the form of a single daily dose of 250 mg until the completion of the 7-day total course of treatment.

The timing of the transition to oral treatment is determined in accordance with the data of the clinical examination.

For patients with moderate hepatic and renal impairment (creatinine clearance> 40 ml / min), dose adjustment is not needed.

Solution preparation rules

The solution for infusion is prepared in 2 stages:

Stage 1 - preparation of the reconstituted solution: 4.8 ml of sterile water for injection is added to a vial with 500 mg of the drug and shaken thoroughly until the powder is completely dissolved. 1 ml of the resulting solution contains 100 mg of azithromycin. The prepared solution remains stable for 24 hours at room temperature.

Stage 2 - dilution of the reconstituted solution (100 mg / ml) is carried out immediately before administration.

The reconstituted solution is added to a vial with a solvent (0.9% sodium chloride solution, 5% dextrose, Ringer's solution) to obtain a final concentration of azithromycin 1-2 mg / ml in the infusion solution.

Hemomycin solution should not be administered intravenously by bolus or intramuscular injection. It is recommended to administer the prepared solution in / in the form of an infusion, drip (dropper) (at least 1 hour).

Before the introduction of the solution is subjected to visual control. If the prepared solution contains particles of the substance, then it should not be used. The prepared solution is stable at room temperature for 24 hours.

Side effect

• diarrhea;
• nausea, vomiting;
• stomach ache;
• dyspepsia;
• flatulence;
• melena;
• constipation;
• anorexia;
• gastritis;
• taste change;
• candidiasis of the oral mucosa;
• heartbeat;
• chest pain;
• dizziness;
• headache;
• drowsiness;
• neurosis;
• vaginal candidiasis;
• nephritis;
• angioedema;
• conjunctivitis;
• hives;
• increased fatigue;
• photosensitivity.

Contraindications

• liver failure;
• kidney failure;
• children's age up to 12 years (for capsules and tablets);
• children's age up to 12 months (for a suspension of 200 mg);
• children's age up to 6 months (for a suspension of 100 mg);
• hypersensitivity to macrolide antibiotics.

Use during pregnancy and lactation

During pregnancy, Hemomycin is prescribed only when the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

If necessary, the use of the drug during lactation should decide whether to stop breastfeeding for the duration of the drug.

Use in children

Contraindicated in children under 12 years of age (for capsules and tablets); children under 12 months (for a suspension of 200 mg); children under 6 months (for a suspension of 100 mg).

special instructions

Do not take the drug during meals.

After discontinuation of treatment in some patients, hypersensitivity reactions may persist, which requires specific therapy and medical monitoring.

drug interaction

With the simultaneous use of Hemomycin and antacids (aluminum- and magnesium-containing), the absorption of azithromycin slows down.

Ethanol (alcohol) and food slow down and reduce the absorption of azithromycin.

With the joint appointment of warfarin and azithromycin (at usual doses), no change in prothrombin time was detected, however, given that the interaction of macrolides and warfarin may increase the anticoagulant effect, patients need careful monitoring of prothrombin time.

The combined use of Hemomycin and digoxin increases the concentration of the latter.

With the simultaneous use of azithromycin with ergotamine and dihydroergotamine, there is an increase in the toxic effect of the latter (vasospasm, dysesthesia).

Co-administration of triazolam and azithromycin reduces clearance and enhances the pharmacological action of triazolam.

Hemomycin slows down the excretion and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine, as well as drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, hexobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine, phenytoin, peror al hypoglycemic agents, theophylline and other xanthine derivatives) - due to the inhibition of microsomal oxidation in hepatocytes by azithromycin.

Lincosamines weaken the effectiveness of azithromycin, while tetracycline and chloramphenicol increase it.

Pharmaceutical interaction

Hemomycin is pharmaceutically incompatible with heparin.

Analogues of the drug Hemomycin

Structural analogues for the active substance:

• Azivok;
• Azimicin;
• Azitral;
• Azitrox;
• Azithromycin;
• Azithromycin Forte;
• AzitRus;
• AzitRus forte;
• Azicide;
• Vero Azithromycin;
• Zetamax retard;
• Zitnob;
• Zitrolide;
• Zitrolide forte;
• Zitrocin;
• Sumazid;
• Sumaclid;
• Sumamed;
• Sumamed forte;
• sumamecin;
• sumamecin forte;
• Sumamox;
• Sumatrolide solutab;
• Tremak Sanovel;
• Ecomed.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.